Pierluigi Valente

Affiliated Researcher

Research Lines



Via Morego, 30


1989-1994: High School at Liceo scientifico "G. GALILEI".

1994-1999: Degree course in Pharmacy, University of Bologna (Italy). Degree thesis entitled: " Effetti modulatori delle variazioni di pH sulle correnti di cloro in astrociti corticali di ratto in coltura " Pharmacy degree, 21th July 1999. Supervisor: Prof. Carmela Rapisarda and Dr. Stefano Ferroni.

1999-2002: PhD-student in Cellular Physiology and Neuroimmunophysiology at Dipartimento di Fisiologia Umana e Generale, Università degli Studi di Bologna (supported by University of Siena).

02/2003: Ph-D degree, thesis entitled: “Electrophysiological and biological effects of arachidonic acid on cultured rat cortical astrocytes” (Thesis advisors: Dr. S. Ferroni, Dr. C. Rapisarda). 

04/2003-2009: Post-doctoral fellowship at the Institute of Molecular and cellular biology, Miguel Hernandez University of Elche, Spain, in the laboratory of Antonio Ferrer Montiel.

01/2010- at the moment: Senior Post-doctoral fellowship at the Italian Institute of Technology (IIT) in Genova, Italy, in the laboratory of Fabio Benfenati and Pietro Baldelli at Department of Neuroscience and Brain Technologies

Selected Publications

Ferroni S., Valente P., Caprini M., Nobile M., Schubert P. and Rapisarda C.: Arachidonic acid activates an open rectifier potassium channel in cultured rat cortical astrocytes. J. Neurosci. Res., 2003 May 1;72(3):363-72.

Porcelli A.M., Ghelli A., Zanna C., Valente P., Ferroni S. and Rugolo M.: Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells. Ann. N. Y. Acad. Sci., 2003 Dec, 1010:342-6.

Porcelli A.M., Ghelli A., Zanna C., Valente P., Ferroni S. And Rugolo M.: Apoptosis induced by staurosporine in ECV304 cells requires cell shrinkage and upregulation of Cl(-) conductance. Cell Death Differ. 2004 Jun, 11(6):655-62.

Caprini .M., Fava M., Valente P., Fernandez Balusters G., Rapisarda C., Ferroni S. and Ferrer-Montiel A.: Molecular compatibility of the channel gate and the N-terminus of S5 segment for voltage-gated channel activity. J Biol. Chem. 2005 May 6;280 (18):18253-64.

Fiebich, B.L., Valente, P., Ferrer-Montiel, A., Candelario-Jalil, E., Menthe, J., Luecker, P. Effects of coffees before and after special treatment procedure on cell membrane potentials in stomach cells. Methods Find Exp Clin Pharmacol. 2006 Jul-Aug; 28(6):369-72.

Garcia Sanz N.*, Valente P*., Gomis Garcia A., Fernandez Carvajal A., Fernandez Ballester G. Viana F., Belmonte C. and Ferrer-Montiel A.  A role of the TRP domain of vanilloid receptor I in channel gating. J. Neurosci. 2007 Oct 24;27(43):11641-50. (*co-authors).

Valente P*., Garcia Sanz N.*, Gomis Garcia A.,; Fernandez Carvajal A., Fernandez Ballester G. Viana F., Belmonte C. and Ferrer-Montiel A.  Identification of molecular determinats of channels gating in the transient receptor potential box of vanilloid receptor I. FASEB J.  2008 ;22 3298-3309. (*co-authors).

Laínez S.*, Valente P.*, Ontoria-Oviedo I., Estévez-Herrera J., Camprubí-Robles M., Ferrer-Montiel A. and Planells-Cases R. GABAA Receptor Associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization. FASEB J. 2010 Jun;24(6):1958-70 (*co-authors).

Valente P., Fernández-Carvajal A., Camprubí-Robles M., Gomis A., Quirce S., Viana F., Fernández-Ballester G., González-Ros J.M., Belmonte C., Planells-Cases R. and Ferrer-Montiel A. Membrane-tethered peptides after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity. FASEB J. 2011 May;25(5):1628-40.

Vidal-Mosquera M., Fernandez A.M., Moure A., Valente P., Planells-Cases R., Gonzalez Ros J.M., Bujons J., Ferrer-Montiel A.V., Messeguer A.; Triazine-based vanilloid-1 receptor open channel blockers: design, synthesis, evaluation and SAR analysis. J. Med. Chem. 2011 Nov 10;54(21):7441-52.

Marconi E., Maccione A., T. Nieus T., Valente P., Messa M., Dante S.,Baldelli P., L. Berdondini L. and Benfenati F.; Emergent functional properties of neuronal networks with long-term controlled topologye. Plos One 2012 ;7(4).

Valente P., Casagrande S., Nieus T., Verstegen A.M.J., Valtorta F., Benfenati F., Baldelli P.; Synapsin  I Phosphorylation Differentially Participates In The Expression Of Post-Tetanic Potentiation And In Its Enhancement By Bdnf. J. Neruosci. 2012 ;25 April 2012, 32(17):5868-5879.


Rosa Planells-Cases, Pierluigi Valente, Antonio Ferrer-Montiel, A., Feng Qin and Arpad Szallasi. Complex regulation of TRPV1 and related thermoTRPs: implications for therapeutic intervention. Chapter 27, Advances in Experimental Medicine and Biology, Volume 704 1115 p., Hardcover, SBN: 978-94-007-0264-6, January 2011.