Giulio Alberini

Visiting scientist
External Collaborator

Research Lines

Center

Contacts

Center for Synaptic Neuroscience (NSYN) Largo Rosanna Benzi 10, Padiglione IST Nord, Torre D, 16132, Genova
+39 010 5558521

Social profiles

linkedin

About

EDUCATION

. Doctoral Level

Nov. 2016 - March 2020. Ph.D. Degree (Dottorato di Ricerca) in Neurosciences (Excellent cum Laude). Università degli Studi di Genova, Genova (Italy). Doctoral Thesis in Applied Physics to Biology and Medicine.

Ph.D. Thesis: Targeting Tight Junctions in Nanomedicine: a Molecular Modeling Perspective. Thesis under the supervision of Dr. Luca Maragliano and Prof. Fabio Benfenati. 

. Pre-Doctoral Level

Oct. 2020 - ongoing. Student enrolled in the M.Sc. Degree (Laurea Magistrale) in Nuclear Engineering. Scuola di Ingegneria, Università degli Studi di Pisa, Pisa (Italy). Training in Nuclear Plants, Nuclear Technologies, Mechanical Engineering.

Oct. 2014 - July 2016. M.Sc. Degree (Laurea Magistrale) in Physics (110/110 cum Laude). Facoltà di Scienze Matematiche, Fisiche e Naturali, Università Cattolica del Sacro Cuore, Brescia (Italy). Training in Matter Physics and Computational Biophysics. Thesis under the supervision of Prof. Alessandro Arcovito. 

M.Sc. Project in Physics (Supervisor Prof. Alessandro Arcovito). Training in Molecular Dynamics (with Dr. Stefano Della Longa) and in Bioinformatics (with Prof. Anna Tramontano).

Oct. 2012 - July 2014. M.Sc. Degree (Laurea Magistrale) in Mathematics (110/110 cum Laude). Facoltà di Scienze Matematiche, Fisiche e Naturali, Università Cattolica del Sacro Cuore, Brescia (Italy). Training in Mathematical Analysis and Mathematical Physics. Thesis under the supervision of Prof. Marco Degiovanni.

PROFESSIONAL EXPERIENCES

Jan. 2021 - ongoing. Istituto Italiano di Tecnologia, Genova (Italy).  External Collaborator with Post-Doctoral duties.

Jan. 2020 - Sept. 2020. University of Leeds, Leeds (England, UK).  Post Doctoral Researcher. 

Sept. 2016 - Dec. 2019. Istituto Italiano di Tecnologia, Genova (Italy). Affiliated Researcher - Ph.D. Student.

Sept. 2015 - July 2016. Istituto di Biochimica e Biochimica Clinica, Policlinico Agostino Gemelli, Roma (Italy).  M.Sc. Project in Physics.

Oct. 2015 -  Jan. 2016. Università degli Studi di Roma "La Sapienza", Roma (Italy). Visiting Student. 

Interests

Computational Biology Computational Biophysics Molecular Dynamics Thermodynamics and Kinetics Calculations Membrane Proteins Mathematical Physics Diffusive Transport Phenomena

Projects

Rare events sampling in membrane proteins. 

Selected Publications

PEER-REVIEWED RESEARCH ARTICLES

1) Alberini G., Benfenati F. and Maragliano L. Structural Mechanism of ω-Currents in a Mutated Kv7.2 Voltage Sensor Domain from Molecular Dynamics Simulations. J. Chem. Inf. Model.2021. Journal IF: 4.549.

2) Malerba F., Alberini G. , Balagura G., Marchese F., Amadori E., Riva A.,  Vari M.S., Gennaro E., Madia F., Salpietro V., Angriman M., Giordano L. Accorsi P., Trivisano M.,  Specchio N., Russo A.,  Gobbi G., Raviglione F., Pisano T.,  Marini C., Mancardi M.M., Nobili L., Freri E., Castellotti B.,  Capovilla G., Coppola A., Verrotti A., Martelli P., Miceli F., Maragliano L., Benfenati F., Cilio M.R.,  Johannesen K.M.,  Møller R.S., Ceulemans B., Minetti C., Weckhuysen S., Zara F., Taglialatela M., Striano P. Genotype-phenotype Correlations in Patients with de novo KCNQ2 Pathogenic Variants. Neurology Genetics, 2020. Journal IF: 3.509.

3) Alberini G., Benfenati F. and Maragliano L. Molecular Dynamics Simulations of Ion Selectivity in a Claudin-15 Paracellular Channel. J. Phys. Chem. B, 2018. Journal IF: 3.146.

4) Alberini G., Benfenati F. and Maragliano L. A Refined Model of Claudin-15 Tight Junction Paracellular Architecture by Molecular Dynamics Simulations. PLOS ONE, 2017, 12, e0184190. Journal IF:  2.806.

 OTHER PUBLICATIONS

5) Bramini M., Alberini G., Colombo E., Chiacchiaretta M., DiFrancesco M. L., Maya-Vetencourt J. F., Maragliano L., Benfenati F., Cesca F. Interfacing Graphene-Based Materials With Neural Cells. Frontiers in Systems Neuroscience, 2018Journal

6) Bramini M., Alberini G., Benfenati F., Maragliano L., Cesca F. Interactions Between 2D Graphene-Based Materials and the Nervous Tissue. Advanced 2D Materials – Characterization, Production and Applications, Publisher: SCIENCE PUBLISHERS (An Imprint of CRC Press/ Taylor & Francis Group), 2018. Book Chapter

 

CONFERENCES
62nd Annual Meeting of the Biophysical Society. San Francisco (USA), 17-21 February 2018. Alberini G., Benfenati F. and Maragliano L. Modeling of Claudin-15 Paracellular Channels via Molecular Dynamics Simulations. [Poster presentation]

IIT Publications

  • 2021
  • Alberini G.iit, Benfenati F.iit, Maragliano L.iit

    Structural Mechanism of ω-Currents in a mutated Kv7.2 voltage sensor domain from molecular dynamics simulations

    Journal of Chemical Information and Modeling
  • 2020
  • Malerba F., Alberini G.iit, Balagura G., Marchese F., Amadori E., Riva A., Vari M. S., Gennaro E., Madia F., Salpietro V., Angriman M., Giordano L., Accorsi P., Trivisano M., Specchio N., Russo A., Gobbi G., Raviglione F., Pisano T., Marini C., Mancardi M. M., Nobili L., Freri E., Castellotti B., Capovilla G., Coppola A., Verrotti A., Martelli P., Miceli F., Maragliano L.iit, Benfenati F.iit, Cilio M. R., Johannesen K. M., Møller R. S., Ceulemans B., Minetti C., Weckhuysen S., Zara F., Taglialatela M., Striano P.
    DOI

    Genotype-phenotype correlations in patients with de novo KCNQ2 pathogenic variants

    Neurology: Genetics
  • 2018
  • Bramini M.iit, Alberini G.iit, Benfenati F.iit, Maragliano L.iit, Cesca F.iit

    Interactions Between 2D Graphene-Based Materials and the Nervous Tissue.

    Advanced 2D Materials – Characterization, Production and Applications, Publisher: SCIENCE PUBLISHERS (An Imprint of CRC Press/ Taylor & Francis Group)
  • Bramini M.iit, Alberini G.iit, Colombo E.iit, Chiacchiaretta M.iit, DiFrancesco M.L.iit, Maya-Vetencourt J.F.iit, Maragliano L.iit, Benfenati F.iit, Cesca F.iit
    DOI

    Interfacing graphene-based materials with neural cells

    Frontiers in Systems Neuroscience, vol. 12
  • Alberini G.iit, Benfenati F.iit, Maragliano L.iit
    DOI

    Molecular Dynamics Simulations of Ion Selectivity in a Claudin-15 Paracellular Channel

    Journal of Physical Chemistry B, vol. 122, (no. 48), pp. 10783-10792
  • 2017
  • Alberini G.iit, Benfenati F.iit, Maragliano L.iit
    DOI

    A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations

    PLoS ONE, vol. 12, (no. 9)

Awards

1. Competitive scholarship provided by the Academic Board of the M. Sc. in Nuclear Engineering, at the University of Pisa.

Jan. 2021

2. Team member. National Class B ISCRA Project for High Performance Computing Resources

June 2019 - June 2020
Winner of a national class B ISCRA project for the use of parallel computing resources (~ 2 300 000 hours) at the CINECA consortium (Principal Investigator Dr. Luca Maragliano).

The proposal includes advanced MD simulations of Voltage Gated Sodium Channels.

 3. Winner of a National Class C ISCRA Project for High Performance Computing Resources

Apr 2019  - Jan. 2020
Winner of a national class C ISCRA project for the use of parallel computing resources (~ 200 000 hours) at the CINECA consortium (as Principal Investigator).

The proposal includes the use of MD simulations to elucidate the genotype-phenotype correlation of pathological mutations of Voltage Gated Potassium Channels.

 4. Team member.  National Class B ISCRA Project for High Performance Computing Resources

Feb. 2018 - Feb. 2019
Winner of a national class B ISCRA project for the use of parallel computing resources (~ 1 700 000 hours) at the CINECA consortium (Principal Investigator Dr. Luca Maragliano).

The proposal includes the main MD simulations for my Ph.D. project.