Elisabetta Colombo

Technologist
Technologist

Research Lines

Center

Contacts

Largo Rosanna Benzi, 10 16132 - Genova (Italy)
+39 010 8610 207
+39 010 555 8534

About

Elisabetta Colombo graduated in Physics of Advanced Technologies at the University of Torino in 2005. From 2005 to 2008 she specialized in materials characterization techniques and carbon based materials properties during the PhD at the Experimental Physics Department at the University of Torino. She worked as post-doc fellow in the following three years at the Electron Devices and Circuits Department at the University of Ulm in Germany: there she designed, fabricated and tested HFCVD diamond sensors for drug-screening and bio-chemical applications, constantly interacting with neuroscientists in Torino (prof. E. Carbone's group) and clinicians in Ulm (Prof. Dr. M. Schneider's group) that were employing the devices. Back to Italy, with an improved background on electrochemistry and cleanroom fabrication technologies, she worked for a short period of time in a small private research laboratory dealing with CVD deposition of TiO2 thin films for dye-sensitized solar cells. She spent subsequently two years employed at Gem Elettronica Srl, an Italian company specialized in radar and navigation systems. In this framework, she experienced how state-of-the-art materials can be successfully integrated at a commercial level, being deputed to the thermal dissipation unit of the R&D department for power transistor systems.

Since then she was employed as post-doc researcher at the Center for Synaptic Neuroscience of IIT in Genova, where she focuses her research on the development and characterization of photosensitive neural interfaces. At IIT, her main activity is related to a novel polymeric device based on photovoltaic conjugated polymers, which is able to modulate neuronal activity upon illumination at a level of membrane potential in cultured neurons, or firing activity in more complex neuronal networks like retina explants or brain slices. Finally, in vivo it has been proven suitable as retinal prosthesis for the recovery of the blind in visually impaired rodents. In addition to this activity, she is involved in the testing of smart materials and devices, like graphene or photosensitive molecules for the modulation of neuronal activity. 

Lately, she bacame Technologist of the NSYN Center to support the development of novel neural interfaces and the engineering of new techniques for the characterization of smart materials for applied neuroscience. 

IIT Publications

  • 2021
  • Gaspar S., Ravasenga T.iit, Munteanu R.-E., David S., Benfenati F.iit, Colombo E.iit
    DOI

    Electrochemically synthesized poly(3-hexylthiophene) nanowires as photosensitive neuronal interfaces

    Materials, vol. 14, (no. 16)
  • 2020
  • DiFrancesco M.L.iit, Colombo E.iit, Papaleo E.D.iit, Manfredi G.iit, Lanzani G.iit, Benfenati F.iit
    DOI

    A hybrid P3HT-Graphene interface for efficient photostimulation of neurons

    Carbon, vol. 162, pp. 308-317
  • Paterno G.M.iit, Colombo E.iit, Vurro V.iit, Lodola F.iit, Cimo S., Sesti V., Molotokaite E.iit, Bramini M.iit, Ganzer L., Fazzi D., D'Andrea C.iit, Benfenati F.iit, Bertarelli C., Lanzani G.iit
    DOI

    Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene

    Advanced Science, vol. 7, (no. 8)
  • Colombo E.iit, Di Marco S.iit, Castagnola V.iit, DiFrancesco M. L., Maya-Vetencourt J. F., Manfredi G., Lanzani G.iit, Benfenati F.iit
    DOI

    Modulation of neuronal firing: what role can nanotechnology play?

    Nanomedicine
  • DiFrancesco M.L.iit, Lodola F.iit, Colombo E.iit, Maragliano L.iit, Bramini M.iit, Paterno G.M.iit, Baldelli P., Serra M.D., Lunelli L., Marchioretto M., Grasselli G.iit, Cimo S.iit, Colella L., Fazzi D., Ortica F., Vurro V.iit, Eleftheriou C.G.iit, Shmal D.iit, Maya-Vetencourt J.F.iit, Bertarelli C.iit, Lanzani G.iit, Benfenati F.iit
    DOI

    Neuronal firing modulation by a membrane-targeted photoswitch

    Nature Nanotechnology, vol. 15, (no. 4), pp. 296-306
  • Maya-Vetencourt J.F.iit, Manfredi G.iit, Mete M., Colombo E.iit, Bramini M.iit, Di Marco S.iit, Shmal D.iit, Mantero G.iit, Dipalo M.iit, Rocchi A.iit, DiFrancesco M.L.iit, Papaleo E.D.iit, Russo A., Barsotti J.iit, Eleftheriou C.iit, Di Maria F., Cossu V., Piazza F., Emionite L., Ticconi F., Marini C., Sambuceti G., Pertile G., Lanzani G.iit, Benfenati F.iit
    DOI

    Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy

    Nature Nanotechnology, vol. 15, (no. 8), pp. 698-708
  • 2019
  • Rocchi A.iit, Moretti D.iit, Lignani G.iit, Colombo E.iit, Scholz-Starke J.iit, Baldelli P., Tkatch T.iit, Benfenati F.iit
    DOI

    Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength

    Molecular Neurobiology, vol. 56, (no. 8), pp. 5701-5714
  • Manfredi G.iit, Colombo E.iit, Barsotti J.iit, Benfenati F.iit, Lanzani G.iit
    DOI

    Photochemistry of Organic Retinal Prostheses

    Annual Review of Physical Chemistry, vol. 70, pp. 99-121
  • 2018
  • Bramini M.iit, Cesca F.iit, Colombo E.iit, DiFrancesco ML.iit, Maya-Vetencourt JF.iit, Alberini G.iit, Maragliano L.iit, Benfenati F.iit
    DOI

    Interfacing graphene-based materials with neural cells.

    Frontiers in Systems Neuroscience
  • 2017
  • Maya-Vetencourt J.F.iit, Ghezzi D.iit, Antognazza M.R.iit, Colombo E.iit, Mete M., Feyen P.iit, Desii A.iit, Buschiazzo A., Di Paolo M., Di Marco S., Ticconi F., Emionite L., Shmal D.iit, Marini C., Donelli I., Freddi G., MacCarone R., Bisti S., Sambuceti G., Pertile G., Lanzani G.iit, Benfenati F.iit
    DOI

    A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness

    Nature Materials, vol. 16, (no. 6), pp. 681-689
  • Vétencourt J.F.iit, Colombo E.iit, Eleftheriou C.iit, DiFrancesco M.iit, Desli A., Zangoli M., DiMaria F., Barbarella G., Pertile G., Lanzani G.iit, Benfenati F.iit

    High-resolution photostimulation strategies with polymeric nano-particles to rescue photoreceptor degeneration

    European Retina Meeting
  • 2016
  • Feyen P.iit, Colombo E.iit, Endeman D.iit, Nova M.iit, Laudato L.iit, Martino N.iit, Antognazza M.R.iit, Lanzani G.iit, Benfenati F.iit, Ghezzi D.iit
    DOI

    Light-evoked hyperpolarization and silencing of neurons by conjugated polymers

    Scientific Reports, vol. 6
  • Colombo E.iit, Feyen P.iit, Antognazza M.R.iit, Lanzani G.iit, Benfenati F.iit
    DOI

    Nanoparticles: A challenging vehicle for neural stimulation

    Frontiers in Neuroscience, vol. 10, (no. MAR)
  • 2015
  • Antognazza M.R.iit, Martino N.iit, Ghezzi D.iit, Feyen P.iit, Colombo E.iit, Endeman D.iit, Benfenati F.iit, Lanzani G.iit
    DOI

    Shedding Light on Living Cells

    Advanced Materials, vol. 27, (no. 46), pp. 7662-7669
  • 2014
  • Gosso S., Turturici M., Franchino C., Colombo E.iit, Pasquarelli A., Carbone E., Carabelli V.
    DOI

    Heterogeneous distribution of exocytotic microdomains in adrenal chromaffin cells resolved by high-density diamond ultra-microelectrode arrays

    Journal of Physiology, vol. 592, (no. 15), pp. 3215-3230
  • Endeman D.iit, Feyen P.iit, Ghezzi D.iit, Antognazza M. R.iit, Martino N.iit, Colombo E.iit, Lanzani G.iit, Benfenati F.iit
    DOI

    The use of light sensitive organic semiconductors to manipulate neuronal activity.

    Advances in Atom and Single Molecule Machines
  • 2011
  • Pasquarelli A., Carabelli V., Xu Y., Colombo E., Gao Z., Scharpf J., Carbone E., Kohn E.
    DOI

    Diamond microelectrodes arrays for the detection of secretory cell activity

    International Journal of Environmental Analytical Chemistry, vol. 91, (no. 2), pp. 150-160
  • Colombo E., Men Y., Scharpf J., Pietzka C., Dipalo M., Herfurth P., Gao Z., Schneider M., Carabelli V., Carbone E., Kohn E., Pasquarelli A.
    DOI

    Fabrication of a NCD microelectrode array for amperometric detection with micrometer spatial resolution

    Diamond and Related Materials, vol. 20, (no. 5-6), pp. 793-797
  • Gao Z., Carabelli V., Carbone E., Colombo E., Dipalo M., Manfredotti C., Pasquarelli A., Feneberg M., Thonke K., Vittone E., Kohn E.
    DOI

    Transparent microelectrode array in diamond technology

    Journal of Micro-Nano Mechatronics, vol. 6, (no. 1), pp. 33-37
  • 2010
  • Carabelli V., Gosso S., Marcantoni A., Xu Y., Colombo E., Gao Z., Vittone E., Kohn E., Pasquarelli A., Carbone E.
    DOI

    Nanocrystalline diamond microelectrode arrays fabricated on sapphire technology for high-time resolution of quantal catecholamine secretion from chromaffin cells

    Biosensors and Bioelectronics, vol. 26, (no. 1), pp. 92-98
  • Gao Z., Carabelli V., Carbone E., Colombo E., Demaria F., Dipalo M., Gosso S., Manfredotti Ch., Pasquarelli A., Rossi S., Xu Y., Vittone E., Kohn E.
    DOI

    Transparent diamond microelectrodes for biochemical application

    Diamond and Related Materials, vol. 19, (no. 7-9), pp. 1021-1026
  • 2009
  • Olivero P., Amato G., Bellotti F., Budnyk O., Colombo E., Jaksic M., Manfredotti C., Pastuovic Z., Picollo F., Skukan N., Vannoni M., Vittone E.
    DOI

    Direct fabrication of three-dimensional buried conductive channels in single crystal diamond with ion microbeam induced graphitization

    Diamond and Related Materials, vol. 18, (no. 5-8), pp. 870-876
  • Colombo E., Bosio A., Calusi S., Giuntini L., Lo Giudice A., Manfredotti C., Massi M., Olivero P., Romeo A., Romeo N., Vittone E.
    DOI

    IBIC analysis of CdTe/CdS solar cells

    Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 267, (no. 12-13), pp. 2181-2184
  • Gao Z., Carabelli V., Carbone E., Colombo E., Dipalo M., Manfredotte Ch., Pasquarelli A., Feneberg M., Thonke K., Vittone E., Kohn E.
    DOI

    Transparent microelectrode array in diamond technology

    2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009, pp. 282-285
  • 2008
  • Colombo E., Calusi S., Cossio R., Giuntini L., Giudice A.L., Mando P.A., Manfredotti C., Massi M., Mirto F.A., Vittone E.
    DOI

    Recent developments of ion beam induced luminescence at the external scanning microbeam facility of the LABEC laboratory in Florence

    Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 266, (no. 8), pp. 1527-1532
  • Vittone E., Pastuovic Z., Olivero P., Manfredotti C., Jaksic M., Lo Giudice A., Fizzotti F., Colombo E.
    DOI

    Semiconductor characterization by scanning ion beam induced charge (IBIC) microscopy

    Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 266, (no. 8), pp. 1312-1318
  • Calusi S., Colombo E., Giuntini L., Giudice A.L., Manfredotti C., Massi M., Pratesi G., Vittone E.
    DOI

    The ionoluminescence apparatus at the LABEC external microbeam facility

    Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 266, (no. 10), pp. 2306-2310
  • 2007
  • Manfredotti C., Jaksic M., Medunic S., Lo Giudice A., Garino Y., Colombo E., Marinelli M., Milani E., Verona-Rinati G.
    DOI

    Ion Beam Induced Charge characterization of epitaxial single crystal CVD diamond

    Diamond and Related Materials, vol. 16, (no. 4-7 SPEC. ISS.), pp. 940-943
  • Fizzotti F., Colombo E., Lo Giudice A., Manfredotti C., Medunic Z., Jaksic M., Vittone E.
    DOI

    Measurement of charge collection profiles in irradiated silicon diodes by lateral IBIC technique

    Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 260, (no. 1), pp. 259-263
  • 2005
  • Manfredotti C., Lo Giudice A., Medunic S., Jaksic M., Colombo E.
    DOI

    Ion beam analysis of single crystal CVD diamond

    Materials Research Society Symposium - Proceedings, vol. 908, pp. 43-49