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Gemma Palazzolo

Affiliated Researcher
Neuroscience and Smart Materials
Research center

Gemma Palazzolo leads the unit of Tissue Engineering in the research line of Enhanced Regenerative Medicine. She is co-PI of the EU H2020 FET PROACTIVE project HERMES, a highly interdisciplinary project, whose long-term vision is to heal  epilepsy, a so far incurable brain disorder characterized by aberrant synaptic transmission and nervous tissue degeneration.

Dr. Palazzolo’s research focus is to engineer bioinspired extracellular matrices that support cell organization into nervous tissue and thus help rebuild the brain matter, damaged or lost due to brain disorders.

Dr. Palazzolo earned her M.Sc. degree in Biotechnologies from the University of Palermo (Italy) in 2007 and, there, she gained her PhD in 2011, with a thesis on proteomic characterization of breast cancer extracellular microvesicles. Following her PhD, she obtained a Postdoctoral fellowship at ETH Zurich (Switzerland) (2011-2014), where she broadened her interests to embrace natural biomolecules, biopolymers and tissue engineering, to regenerate body tissues like cartilage and brain. In 2015 she moved to IIT, as Postdoctoral fellow, where she has run a broad range of activities, which include: i) developing in vitro brain tissue structures; ii) exploiting optical approaches to monitor and/or modulate the functional connectivity of neural networks; iii) establishing patient derived tumor spheroids as in vitro platforms for drug screening.

Dr. Palazzolo has been visiting scientist, during her PhD, at FHNW Basel (Switzerland), in 2009-2010; and visiting Postdoc at Tampere University (Finland), in 2014, in the context of the 3DNeuroN project (FP7-ICT 2012-2015; http://www.3dneuron.eu/).

Gemma Palazzolo holds patents on tissue engineering, cell manipulation and volumetric imaging.


2019    G. Palazzolo (co-PI) Hybrid Enhanced Regenerative Medicine Systems – HERMES. EU H2020 (FETPROACT-2018-2020 GA n.824164) 



All Publications
Forro C., Caron D., Angotzi G.N., Gallo V., Berdondini L., Santoro F., Palazzolo G., Panuccio G.
Electrophysiology read-out tools for brain-on-chip biotechnology
Micromachines, vol. 12, (no. 2), pp. 1-50
Palazzolo G., Mollica H., Lusi V., Rutigliani M., Di Francesco M., Pereira R.C., Filauro M., Paleari L., DeCensi A., Decuzzi P.
Modulating the Distant Spreading of Patient-Derived Colorectal Cancer Cells via Aspirin and Metformin
Translational Oncology, vol. 13, (no. 4)
Deguchi T., Bianchini P., Palazzolo G., Oneto M., Diaspro A., Duocastella M.
Volumetric Lissajous confocal microscopy with tunable spatiotemporal resolution
Biomedical Optics Express, vol. 11, (no. 11), pp. 6293-6310
Ciarpella F., Zamfir R., Campanelli A., Di Chio M., Pedrotti G., Dolci S., Mannino L., Fumagalli G., Curia G., Panuccio G., Palazzolo G., Decimo I.
Generation of 3D brain organoids to recapitulate hippocampal structure
European Organoids Symposium
Poster Conference
Broguiere N., Husch A., Palazzolo G., Bradke F., Madduri S., Zenobi-Wong M.
Macroporous hydrogels derived from aqueous dynamic phase separation
Biomaterials, vol. 200, pp. 56-65