Pietro Baldelli

Affiliated Researcher
Consultant Scientist

Contacts

Via Morego, 30
+39 010 353 8191
+39 3336593122

About

Pietro Baldelli graduated in Biological Science at the University of Genova, he accomplished his PhD studies in Cellular Physiology and Neuroimmunophysiology at the University of Torino and he had a position of Associate Researcher at the Dept. of Molecular Physiology and Biophysic, Baylor College of Medicine, Houston, TX. He came back to Italy with an independent Researcher position at the National Institute for Physics of the Matter, Dept. of Neuroscience, University of Torino and he is actually Consultant Scientist at the IIT and Associate  Professor at the Dept. of Experimental Medicine, University of Genova, where he teaches courses on Human Physiology, Neurophysiology and Electrophysiological Technologies. His main subjects of investigation, in the last 15 years, have been the molecular mechanisms underlying both physiological and pathological processes of the neurotransmission that he has investigated at different levels, from the single synapse to the complexity of the neuronal network by using a combination of various electrophysiological approaches. He developed his research activities in collaboration with leading international scientists, acquiring a recognized experience of quantal analysis in synaptic transmission and plasticity. He has a strong biophysical and neurophysiological background, and a proved experience in the project management and coordination. Pietro Baldelli is author of 43 papers in refereed journals and many others in conference proceedings and books and he has been paper reviewer for: The Journal of Neuroscience, The American Journal of Physiology and The European Journal of Pharmacology

 

Autore di 66 lavori su riviste internazionali.

Autore di 10 articoli su proceedings o libri.

Autore di oltre 100 comunicazioni a Congressi Internazionali e oltre 100 a Congressi Nazionali.

Dati SCOPUS:

H-index totale:         33

Citazioni totali:       2352

Dati: Google Scholar

H-index totale:         34

Citazioni totali:         3013

 

Principali Finanziamenti Ottenuti (2019 al 2009)

-Contributo Fondazione di San Paolo (2007-2010); Titolo del progetto: “EFFETTI DELLE NEUROTROFINE SUL RILASCIO DI NEUROTRASMETTITORE E SULLA PLASTICITA'  SINAPTICA”.

Role: Principal Investigator.

-Bando Giovani Ricercatori (2008-2011) - Ministero della Salute – Direzione Generale della Ricerca Scientifica e Tecnologica. Titolo del progetto: “IDENTIFICATION OF THE EPILEPTOGENIC AREA AND THE MECHANISMS OF SEIZURE GENERATION IN FOCAL EPILEPSY”. Role: Principal Investigator

-Telethon Fundation. (2009-2012). Project Title: "L1-CAM-disease (CRASH syndrome): EXPRESSION AND SYNAPTIC ROLE OF L1-CAM AND ITS MUTATIONS; PHARMACOLOGY OF ITS SIGNALING.”  # GRANT N. GGP09066a.  Role: Principal Investigator

-Progetti di Ricerca Ateneo (2010-2011) - UNIGE - (ex 60%) Titolo del progetto RUOLO DEL FATTORE DI TRASCRIZIONE NEGATIVO NRSF/REST NELL’EPILETTOGENESI di UN MODELLO MURINO DI EPILESSIA UMANA.Role: Principal Investigator.

-Bando Giovani Ricercatori (2011-2015) - Ministero della Salute – Direzione Generale della Ricerca Scientifica e Tecnologica.  Project Title: GENETIC AND FUNCTIONAL ANALYSIS OF COPY NUMBER VARIATIONS (CNVs) AFFECTING ION CHANNEL GENES IN FAMILIAL IDIOPATHIC GENERALIZED EPILEPSY – Codice Progetto: GR-2009-1473821: in convenzione con Istituto Gaslini. Role: Principal Investigator dell’Unità UniGe

-Progetti di Ricerca Ateneo (2012-2013) - UNIGE - (ex 60%) Titolo del progetto: RUOLO DELLA GLICOPROTEINA DI ADESIONE L1-CAM NELLA PLASTICITÀ SINAPTICA DEI CIRCUITI IPPOCAMPALI Finanziamento: Role: Principal Investigator.

-Cariplo Foundation - Technology Call. (2014-16) Project: "UMANA: ULTRASENSITIVE MAGNETIC ARRAY FOR RECORDING OF NEURONAL ACTIVITY". Role: Responsabile Unità Elettrofisiologia.

-Cariplo Foundation - (2014-16) - Health Call. Project: "ROLE OF THE PRESYNAPTIC PROTEIN PRRT2 IN THE PATHOGENESIS OF NEUROLOGICAL PAROXYSMAL DISORDERS".  Role:Responsabile Unità Elettrofisiologia

-EU Horizon 2020. Call: H2020-MSCA-ITN-2014. (2015-2018) Project Title: “THE EXTRACELLULAR MATRIX IN EPILEPTOGENESIS”. Role:Responsabile Unità Elettrofisiologia

 -Italian Ministry of Research - PRIN Multicentre ProjectEXCITATORY/INHIBITORY BALANCE IN THE CENTRAL NERVOUS SYSTEM: SYNAPTIC TRANSMISSION, PLASTICITY AND SYNAPTOPATHIES -Role: Responsabile Unità Elettrofisiologia

-Fondazione Compagnia di San Paolo (2018-2021) - Titolo del Progetto: Meccanismo d'azione ed applicazione della dieta ipoglicemica per la prevenzione dell’epilettogenesi in modelli di epilessia genetica umana”- ID ROL:20612. Role: Principal Investigator.

 

Projects

A common way to explain seizures is the disruption of the normal balance between excitatory and inhibitory input. Increasing evidence showed that epileptogenetic processes transform a normal neuronal network in a hyperexcitable network through multiple mechanisms of altered synaptic and intrinsic plasticity. Goal of our project is the elucidation of the electrophysiological and molecular mechanisms underlying altered plasticity at the basis of epileptogenesis.

IIT Publications

  • 2019
  • Rocchi A.iit, Moretti D.iit, Lignani G.iit, Colombo E.iit, Scholz-Starke J.iit, Baldelli P., Tkatch T.iit, Benfenati F.iit
    DOI

    Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength

    Molecular Neurobiology
  • Prestigio C.iit, Ferrante D., Valente P., Casagrande S., Albanesi E.iit, Yanagawa Y., Benfenati F.iit, Baldelli P.
    DOI

    Spike-Related Electrophysiological Identification of Cultured Hippocampal Excitatory and Inhibitory Neurons

    Molecular Neurobiology
  • 2018
  • Bosco F., Valente P., Milanese M., Piccini A., Messa M.iit, Bonanno G., Lombroso P., Baldelli P.iit, Benfenati F.iit, Giovedi S.
    DOI

    Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice

    Molecular Neurobiology, vol. 55, (no. 10), pp. 8084-8102
  • Moretti D.iit, DiFrancesco M.L.iit, Sharma P.P., Dante S., Albisetti E., Monticelli M., Bertacco R., Petti D., Baldelli P.iit, Benfenati F.iit
    DOI

    Biocompatibility of a magnetic tunnel junction sensor array for the detection of neuronal signals in culture

    Frontiers in Neuroscience
  • Valente P., Romei A.iit, Fadda M., Sterlini B.iit, Lonardoni D.iit, Forte N.iit, Fruscione F., Castroflorio E.iit, Michetti C.iit, Giansante G., Valtorta F., Tsai J.W., Zara F., Nieus T., Corradi A.iit, Fassio A.iit, Baldelli P.iit, Benfenati F.iit
    DOI

    Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons

    Cerebral Cortex
  • Fruscione F., Valente P., Sterlini B.iit, Romei A.iit, Baldassari S., Fadda M., Prestigio C.iit, Giansante G., Sartorelli J., Rossi P., Rubio A., Gambardella A., Nieus T., Broccoli V., Fassio A.iit, Baldelli P.iit, Corradi A.iit, Zara F., Benfenati F.iit
    DOI

    PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity

    Brain, vol. 141, (no. 4), pp. 1000-1016
  • Pecoraro-Bisogni F.iit, Lignani G.iit, Contestabile A.iit, Castroflorio E.iit, Pozzi D.iit, Rocchi A.iit, Prestigio C.iit, Orlando M.iit, Valente P., Massacesi M.iit, Benfenati F.iit, Baldelli P.iit
    DOI

    REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity

    Molecular Neurobiology, vol. 55, (no. 6), pp. 4959-4972
  • Barbieri R., Contestabile A.iit, Ciardo M.G., Forte N.iit, Marte A., Baldelli P.iit, Benfenati F.iit, Onofri F.
    DOI

    Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice

    Oncotarget, vol. 9, (no. 27), pp. 18760-18774
  • 2017
  • Parrini M.iit, Ghezzi D.iit, Deidda G.iit, Medrihan L.iit, Castroflorio E.iit, Alberti M.iit, Baldelli P.iit, Cancedda L.iit, Contestabile A.iit
    DOI

    Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

    Scientific Reports, vol. 7, (no. 1)
  • Valente P., Farisello P.iit, Valtorta F., Baldelli P.iit, Benfenati F.iit
    DOI

    Impaired GABAB-mediated presynaptic inhibition increases excitatory strength and alters short-term plasticity in synapsin knockout mice

    Oncotarget, vol. 8, (no. 52), pp. 90061-90076
  • Michetti C.iit, Castroflorio E.iit, Marchionni I.iit, Forte N.iit, Sterlini B., Binda F.iit, Fruscione F., Baldelli P.iit, Valtorta F., Zara F., Corradi A.iit, Benfenati F.iit
    DOI

    The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations

    Neurobiology of Disease, vol. 99, pp. 66-83
  • Sharma P.P., Gervasoni G., Albisetti E., D'Ercoli F., Monticelli M., Moretti D.iit, Forte N.iit, Rocchi A.iit, Ferrari G., Baldelli P.iit, Sampietro M., Benfenati F.iit, Bertacco R., Petti D.
    DOI

    Towards a magnetoresistive platform for neural signal recording

    AIP Advances, vol. 7, (no. 5)
  • 2016
  • Forte N.iit, Medrihan L.iit, Cappetti B.iit, Baldelli P.iit, Benfenati F.iit
    DOI

    2-Deoxy-d-glucose enhances tonic inhibition through the neurosteroid-mediated activation of extrasynaptic GABAA receptors

    Epilepsia, vol. 57, (no. 12), pp. 1987-2000
  • Valente P., Lignani G.iit, Medrihan L.iit, Bosco F., Contestabile A.iit, Lippiello P., Ferrea E.iit, Schachner M., Benfenati F.iit, Giovedi S., Baldelli P.iit
    DOI

    Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels

    Journal of Cell Science, vol. 129, (no. 9), pp. 1878-1891
  • Valente P.iit, Orlando M.iit, Raimondi A.iit, Benfenati F.iit, Baldelli P.iit
    DOI

    Fine Tuning of Synaptic Plasticity and Filtering by GABA Released from Hippocampal Autaptic Granule Cells

    Cerebral Cortex, vol. 26, (no. 3), pp. 1149-1167
  • Valente P., Castroflorio E.iit, Rossi P., Fadda M., Sterlini B.iit, Cervigni R.I., Prestigio C.iit, Giovedi S., Onofri F., Mura E., Guarnieri F.C., Marte A., Orlando M.iit, Zara F., Fassio A.iit, Valtorta F., Baldelli P.iit, Corradi A., Benfenati F.iit
    DOI

    PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release Machinery

    Cell Reports, vol. 15, (no. 1), pp. 117-131
  • 2015
  • Medrihan L.iit, Ferrea E.iit, Greco B.iit, Baldelli P.iit, Benfenati F.iit
    DOI

    Asynchronous GABA release is a key determinant of tonic inhibition and controls neuronal excitability: A study in the synapsin II-/- mouse

    Cerebral Cortex, vol. 25, (no. 10), pp. 3356-3368
  • Baldelli P.iit, Meldolesi J.
    DOI

    The transcription repressor REST in adult neurons: Physiology, pathology, and diseases

    eNeuro, vol. 2, (no. 4)
  • 2014
  • Orlando M.iit, Lignani G.iit, Maragliano L.iit, Fassio A.iit, Onofri F., Baldelli P.iit, Giovedi S., Benfenati F.iit
    DOI

    Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics

    Journal of Neuroscience, vol. 34, (no. 44), pp. 14752-14768
  • Gonzalez J.C., Lignani G.iit, Maroto M., Baldelli P.iit, Hernandez-Guijo J.M.
    DOI

    Presynaptic muscarinic receptors reduce synaptic depression and facilitate its recovery at hippocampal GABAergic synapses

    Cerebral Cortex, vol. 24, (no. 7), pp. 1818-1831
  • Falace A., Buhler E., Fadda M.iit, Watrin F., Lippiello P., Pallesi-Pocachard E., Baldelli P.iit, Benfenati F.iit, Zara F., Represa A., Fassio A.iit, Cardoso C.
    DOI

    TBC1D24 regulates neuronal migration and maturation through modulation of the ARF6-dependent pathway

    Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 6), pp. 2337-2342
  • 2013
  • Toader O.iit, Forte N.iit, Orlando M.iit, Ferrea E.iit, Raimondi A.iit, Baldelli P.iit, Benfenati F.iit, Medrihan L.iit
    DOI

    Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

    Frontiers in Cellular Neuroscience, (no. AUG)
  • Lignani G.iit, Raimondi A.iit, Ferrea E.iit, Rocchi A.iit, Paonessa F.iit, Cesca F.iit, Orlando M.iit, Tkatch T.iit, Valtorta F., Cossette P., Baldelli P.iit, Benfenati F.iit
    DOI

    Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity

    Human Molecular Genetics, vol. 22, (no. 11), pp. 2186-2199
  • Lignani G.iit, Ferrea E.iit, Difato F.iit, Amaru J., Ferroni E., Lugara E., Espinoza S.iit, Gainetdinov R.R.iit, Baldelli P.iit, Benfenati F.iit
    DOI

    Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity

    Frontiers in Molecular Neuroscience, (no. JUNE)
  • Pozzi D.iit, Lignani G.iit, Ferrea E.iit, Contestabile A.iit, Paonessa F.iit, D'Alessandro R., Lippiello P.iit, Boido D., Fassio A.iit, Meldolesi J., Valtorta F., Benfenati F.iit, Baldelli P.iit
    DOI

    REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

    EMBO Journal, vol. 32, (no. 22), pp. 2994-3007
  • Medrihan L.iit, Cesca F.iit, Raimondi A.iit, Lignani G.iit, Baldelli P.iit, Benfenati F.iit
    DOI

    Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

    Nature Communications, vol. 4
  • Farisello P.iit, Boido D.iit, Nieus T.iit, Medrihan L.iit, Cesca F.iit, Valtorta F., Baldelli P.iit, Benfenati F.iit
    DOI

    Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice

    Cerebral Cortex, vol. 23, (no. 3), pp. 581-593
  • 2012
  • Marconi E.iit, Nieus T.iit, Maccione A.iit, Valente P.iit, Simi A.iit, Messa M.iit, Dante S.iit, Baldelli P.iit, Berdondini L.iit, Benfenati F.iit
    DOI

    Emergent functional properties of neuronal networks with controlled topology

    PLoS ONE, vol. 7, (no. 4)
  • Scholz-Starke J.iit, Cesca F.iit, Schiavo G., Benfenati F.iit, Baldelli P.iit
    DOI

    Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons

    PLoS ONE, vol. 7, (no. 4)
  • Cesca F.iit, Yabe A., Spencer-Dene B., Scholz-Starke J.iit, Medrihan L.iit, Maden C.H., Gerhardt H., Orriss I.R., Baldelli P.iit, Al-Qatari M., Koltzenburg M., Adams R.H., Benfenati F.iit, Schiavo G.
    DOI

    Kidins220ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems

    Cell Death and Differentiation, vol. 19, (no. 2), pp. 194-208
  • Ferres E.iit, Maccione A.iit, Medrihan L.iit, Nieui T.iit, Ghezzi D.iit, Baldelli P.iit, Benfenati F.iit, Berdondini L.iit
    DOI

    Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

    Frontiers in Neural Circuits, (no. NOV), pp. 1-14
  • Valente P.iit, Casagrande S., Nieus T.iit, Verstegen A.M.J.iit, Valtorta F., Benfenati F.iit, Baldelli P.iit
    DOI

    Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF

    Journal of Neuroscience, vol. 32, (no. 17), pp. 5868-5879
  • 2011
  • Cesca F.iit, Baldelli P.iit, Valtorta F., Benfenati F.iit
    DOI

    Corrigendum to "The synapsins: Key actors of synapse function and plasticity" [Prog. Neurobiol. 91 (4) (2010) 313-348]

    Progress in Neurobiology, vol. 93, (no. 4)
  • Gonzalez J.C., Albinana E., Baldelli P.iit, Garcia A.G., Hernandez-Guijo J.M.
    DOI

    Presynaptic muscarinic receptor subtypes involved in the enhancement of spontaneous GABAergic postsynaptic currents in hippocampal neurons

    European Journal of Neuroscience, vol. 33, (no. 1), pp. 69-81
  • Fassio A., Patry L., Congia S.iit, Onofri F., Piton A., Gauthier J., Pozzi D.iit, Messa M.iit, Defranchi E.iit, Fadda M.iit, Corradi A., Baldelli P.iit, Lapointe L., St-Onge J., Meloche C., Mottron L., Valtorta F., Nguyen D.K., Rouleau G.A., Benfenati F.iit, Cossette P.
    DOI

    SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function

    Human Molecular Genetics, vol. 20, (no. 12), pp. 2297-2307
  • Fassio A., Raimondi A.iit, Lignani G.iit, Benfenati F.iit, Baldelli P.iit
    DOI

    Synapsins: From synapse to network hyperexcitability and epilepsy

    Seminars in Cell and Developmental Biology, vol. 22, (no. 4), pp. 408-415
  • 2010
  • Musazzi L., Milanese M., Farisello P.iit, Zappettini S., Tardito D., Barbiero V.S., Bonifacino T., Mallei A., Baldelli P.iit, Racagni G.iit, Raiteri M., Benfenati F.iit, Bonanno G., Popoli M.
    DOI

    Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: The dampening action of antidepressants

    PLoS ONE, vol. 5, (no. 1)
  • Boido D.iit, Farisello P.iit, Cesca F.iit, Ferrea E.iit, Valtorta F., Benfenati F.iit, Baldelli P.iit
    DOI

    Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: Age-dependency and response to the antiepileptic drug levetiracetam

    Neuroscience, vol. 171, (no. 1), pp. 268-283
  • Cesca F.iit, Baldelli P.iit, Valtorta F., Benfenati F.iit
    DOI

    The synapsins: Key actors of synapse function and plasticity

    Progress in Neurobiology, vol. 91, (no. 4), pp. 313-348
  • 2009
  • Bianchi V., Farisello P.iit, Baldelli P.iit, Meskenaite V., Milanese M., Vecellio M., Muhlemann S., Lipp H.P., Bonanno G., Benfenati F.iit, Toniolo D., D'Adamo P.
    DOI

    Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training

    Human Molecular Genetics, vol. 18, (no. 1), pp. 105-117
  • Chiappalone M.iit, Casagrande S., Tedesco M., Valtorta F., Baldelli P.iit, Martinoia S.iit, Benfenati F.iit
    DOI

    Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of synapsin i-deficient cortical networks

    Cerebral Cortex, vol. 19, (no. 6), pp. 1422-1439
  • 2008
  • Arnaiz-Cot J.J., Gonzalez J.C., Sobrado M., Baldelli P.iit, Carbone E., Gandia L., Garcia A.G., Hernandez-Guijo J.M.
    DOI

    Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission

    European Journal of Neuroscience, vol. 27, (no. 5), pp. 1097-1110
  • 2007
  • Baldelli P.iit, Fassio A.iit, Valtorta F.iit, Benfenati F.iit
    DOI

    Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses

    Journal of Neuroscience, vol. 27, (no. 49), pp. 13520-13531
  • 2006
  • Collo G., Goffi F., Merlo Pich E., Baldelli P., Benfenati F., Spano P.
    DOI

    Immature neuronal phenotype derived from mouse skin precursor cells differentiated in vitro

    Brain Research, vol. 1109, (no. 1), pp. 32-36
  • Menegon A., Bonanomi D., Albertinazzi C., Lotti F., Ferrari G., Kao H.-T., Benfenati F., Baldelli P., Valtorta F.iit
    DOI

    Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity

    Journal of Neuroscience, vol. 26, (no. 45), pp. 11670-11681
  • 2005
  • Ariano P., Baldelli P., Carbone E., Gilardino A., Lo Giudice A., Lovisolo D., Manfredotti C., Novara M., Sternschulte H., Vittone E.
    DOI

    Cellular adhesion and neuronal excitability on functionalised diamond surfaces

    Diamond and Related Materials, vol. 14, (no. 3-7), pp. 669-674
  • Baldelli P., Fassio A., Corradi A., Cremona O., Valtorta F., Benfenati F.

    Synapsins and neuroexocytosis: Recent views from functional studies on synapsin null mutant mice

    Archives Italiennes de Biologie, vol. 143, (no. 2), pp. 113-126