Michael Gunnar Thor

Post Doc
Postdoctoral researcher

Contacts

CBA Advanced Biotechnology Center, Largo Rosanna Benzi, 16132 Genova

Interests

Molecular neuroscience cellular neuroscience systems neuroscience neurological disease

Selected Publications

2018

Dysfunction of the skeletal muscle voltage gated sodium channel in sudden infant death syndrome. (2018) R. Männikkö*, L. Wong*, D. J. Tester, M.G. Thor, R. Sud, D.M. Kullmann, M.G. Sweeney, C. Leu, S.M. Sisodiya, D.R. Fitzpatrick, M.J. Evans, I.J.M. Jeffrey, J.Tfelt-Hansen, M.C. Cohen, P.J. Fleming, A. Jaye, M. A. Simpson, M.J. Ackerman, M.G. Hanna, E.R. Behr and E. Matthews. (2018)
Lancet.
Accepted. Third author. (*Joint first author)

Spider toxin inhibits gating pore currents underlying periodic paralysis. Roope Männikkö*, Zakhar O. Shenkarev*, Michael G. Thor, … , Dimitri M. Kullmann, Alexander A. Vassilevski
PNAS. 2018. Accepted. Second author. (*Joint first author)


2017

Congenital myopathy with "corona" fibres, selective muscle atrophy, and craniosynostosis associated with novel recessive mutations in SCN4A. (2017) Gonorazky HD, Marshall CR, Al-Murshed M, Hazrati LN, Thor MG, Hanna MG, Männikkö R, Ray PN, Yoon G. 
Neuromuscular Disorders.  Peer-reviewed. http://dx.doi.org/10.1016/j.nmd.2017.02.001

2016

Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or 'classical' congenital myopathy. (2016) Zaharieva IT*, Thor MG*, Oates EC*, van Karnebeek C, Hendson G, Blom E, Witting N, Rasmussen M, Gabbett MT, Ravenscroft G, Sframeli M, Suetterlin K, Sarkozy A, D'Argenzio L, Hartley L, Matthews E, Pitt M, Vissing J, Ballegaard M, Krarup C, Slørdahl A, Halvorsen H, Ye XC, Zhang LH, Løkken N, Werlauff U, Abdelsayed M, Davis MR, Feng L, Phadke R, Sewry CA, Morgan JE, Laing NG, Vallance H, Ruben P, Hanna MG, Lewis S, Kamsteeg EJ, Männikkö R, Muntoni F. 
Brain. Peer-reviewed. *Joint first author. doi:10.1093/brain/awv352

Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli. (2016) Thor MG, Morris G. 
J. Neurophysiology.
Peer-reviewed. doi:10.1152/jn.00031.2016

 

Congenital myopathy with "corona" fibres, selective muscle atrophy, and craniosynostosis
associated with novel recessive mutations in SCN4A. Gonorazky HD, Marshall CR, Al-Murshed M, Hazrati LN, Thor MG, Hanna MG, Männikkö R, Ray PN, Yoon G. (2017). Neuromuscular Disorders. Peer-reviewed. http://dx.doi.org/10.1016/j.nmd.2017.02.001

IIT Publications

  • 2018
  • Mannikko R., Wong L., Tester D.J., Thor M.G., Sud R., Kullmann D.M., Sweeney M.G., Leu C., Sisodiya S.M., FitzPatrick D.R., Evans M.J., Jeffrey I.J.M., Tfelt-Hansen J., Cohen M.C., Fleming P.J., Jaye A., Simpson M.A., Ackerman M.J., Hanna M.G., Behr E.R., Matthews E.
    DOI

    Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study

    The Lancet, vol. 391, (no. 10129), pp. 1483-1492
  • Mannikko R., Shenkarev Z.O., Thor M.G., Berkut A.A., Myshkin M.Y., Paramonov A.S., Kulbatskii D.S., Kuzmin D.A., Sampedro-Castaneda M., King L., Wilson E.R., Lyukmanova E.N., Kirpichnikov M.P., Schorge S., Bosmans F., Hanna M.G., Kullmann D.M., Vassilevski A.A.
    DOI

    Spider toxin inhibits gating pore currents underlying periodic paralysis

    Proceedings of the National Academy of Sciences of the United States of America, vol. epub
  • 2017
  • Gonorazky H.D., Marshall C.R., Al-Murshed M., Hazrati L.-N., Thor M.G., Hanna M.G., Mannikko R., Ray P.N., Yoon G.
    DOI

    Congenital myopathy with “corona” fibres, selective muscle atrophy, and craniosynostosis associated with novel recessive mutations in SCN4A

    Neuromuscular Disorders, vol. 27, (no. 6), pp. 574-580
  • 2016
  • Thor M.G., Morris G.
    DOI

    Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli.

    Journal of Neurophysiology, vol. 116, (no. 5), pp. 2001-2003
  • Thor M.G., Männikkö R., Shenkarev Z.O., Berkut A.A., Myshkin M.Y., Paramonov A.S., Kulbatskii D.S., Kuzmin D.A., Sampedro Castañeda M., King L., Wilson E.R., Lyukmanova E.N., Kirpichnikov M.P., Schorge S., Bosmans F., Hanna M.G., Kullmann D.M., Vassilevski A.A.

    Gating pore currents in novel S4 arginine mutant NaV1.4 channels: myotonia and block by Heriaeus melloteei spider toxin

    Annual Meeting of the Society for Neuroscience 2016
  • Thor M.G., Zaharieva I.T., Oates E.C., van Karnebeek C., Hendson G., Blom E., Witting N., Rasmussen M., Gabbett M.T., Ravenscroft G., Sframeli M., Suetterlin K., Sarkozy A., D'Argenzio L., Hartley L., Matthews E., Pitt M., Vissing J., Ballegaard M., Krarup C., Slørdahl A., Halvorsen H., Ye X.C., Zhang L.H., Løkken N., Werlauff U., Abdelsayed M., Davis M.R., Feng L., Phadke R., Sewry C.A., Morgan J.E., Laing N.G., Vallance H., Ruben P., Hanna M.G., Lewis S., Kamsteeg E.J., Männikkö R., Muntoni F.

    Loss of function mutations in SCN4A cause severe fetal hypokinesia or "classical" congenital myopathy

    OXION Annual Ion Channels Day
  • Zaharieva I.T., Thor M.G., Oates E.C., Van Karnebeek C., Hendson G., Blom E., Witting N., Rasmussen M., Gabbett M.T., Ravenscroft G., Sframeli M., Suetterlin K., Sarkozy A., D'Argenzio L., Hartley L., Matthews E., Pitt M., Vissing J., Ballegaard M., Krarup C., Slordahl A., Halvorsen H., Ye X.C., Zhang L.-H., Lokken N., Werlauff U., Abdelsayed M., Davis M.R., Feng L., Phadke R., Sewry C.A., Morgan J.E., Laing N.G., Vallance H., Ruben P., Hanna M.G., Lewis S., Kamsteeg E.-J., Mannikko R., Muntoni F.
    DOI

    Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or 'classical' congenital myopathy

    Brain, vol. 139, (no. 3), pp. 674-691
  • 2015
  • Thor M.G., Zaharieva I.T., Oates E.C., van Karnebeek C., Hendson G., Blom E., Witting N., Rasmussen M., Gabbett M.T., Ravenscroft G., Sframeli M., Suetterlin K., Sarkozy A., D'Argenzio L., Hartley L., Matthews E., Pitt M., Vissing J., Ballegaard M., Krarup C., Slørdahl A., Halvorsen H., Ye X.C., Zhang L.H., Løkken N., Werlauff U., Abdelsayed M., Davis M.R., Feng L., Phadke R., Sewry C.A., Morgan J.E., Laing N.G., Vallance H., Ruben P., Hanna M.G., Lewis S., Kamsteeg E.J., Männikkö R., Muntoni F.

    Recessive loss of function SCN4A mutations associated with a novel phenotype of congenital myopathy

    OXION Ion Channels Day
  • 2014
  • Thor M.G., Durran S., Männikkö R., Kuzmin D.A., Sampedro Castañeda M., King L., Wilson E.R., Schorge S., Hanna M.G., Kullmann D.M.

    Mutations of the same S4 arginine residue in NaV1.4 can result in either myotonia or hypokalemic periodic paralysis

    UCL Neuroscience Symposium
  • Thor M.G., Durran S., Männikkö R., Kuzmin D.A., Sampedro Castañeda M., Schorge S., Hanna M.G., Kullmann D.M.

    NaV1.4 dysfunction leading to myotonia with periodic paralysis

    Queen Square Symposium

Awards

Queen Square Prize in Neurology 2017 (Awarded at the UCL Institute of Neurology)

Poster Prize - Functional Genomics Unit, University of Oxford 2015

Guarantors of Brain Travel Grant