Fanny Jaudon obtained a Master degree in Neuroscience at the University of Montpellier, France in 2008. She then joined the laboratory of Anne Debant at the Cell Biology Research Center of Montpellier for her PhD, investigating the importance of Rho GTPases and their activators, Rho GEFs in dendritogenesis and spine formation.
She joined the Italian Institute of Technology (IIT) as a postdoctoral researcher in June 2014, first working with Dr Fabrizia Cesca on the molecular mechanisms regulating neuronal excitability and formation of functional brain circuits, through the characterization of the role of the scaffold protein Kidins220 in the mature neurons and in astrocytes.
Since November 2016 she is working in the group of Dr Lorenzo Cingolani on the role of integrins in cortical circuits function and investigating their potential as molecular target for the development of autism spectrum disorders (ASD) therapies using genome-editing approaches.
Genome-editing approaches for personalized medicine in inherited diseases
This project aims to developing novel strategies for personalized medicine in inherited brain diseases with a complex and multifactorial genetic architecture. To this end, I am developing a CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9)-based strategy to modulate integrin expression in neurons to rescue behavioral and synaptic deficits in a mouse model of ASDs.
Thalhammer A, Jaudon F and Cingolani LA. Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits. J Vis Exp. 2018 Mar 14;(133). doi: 10.3791/57223. PubMed PMID: 29608168.
Jaudon F, Raynaud F, Wehrlé R, Bellanger JM, Doulazmi M, Vodjdani, Gasman S, Fagni l, Dusart I, Debant A and Schmidt S. The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol Biol Cell. 2015 Jun 1;26(11):2112-27.
Lebrun C, Avci HX, Wehrlé R, Doulazmi M, Jaudon F, Morel MP, Rivals I, Ema M, Schmidt S, Sotelo C, Vodjdani G, and Dusart I. Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture. Mol Cell Neurosci. 2012 Nov 29.
Bouslama-Oueghlani L, Wehrlé R, Doulazmi M, Chen X, Jaudon F, Lemaigre- Dubreuil Y, Rivals I, Sotelo C, and Dusart I. Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of Sonic Hedgehog and Vitronectin. PLOS One 2012 ;7(11):e49015.
Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA. A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development 2011 Dec;138(23):5177-88.
Lassot I, Robbins I, Kristiansen M, Rahmeh R, Jaudon F, Magiera MM, Mora S, Vanhille L, Lipkin A, Pettmann B, Ham J, Desagher S. Trim17, a novel E3 ubiquitin- ligase, initiates neuronal apoptosis. Cell Death Differ 2010 Dec;17(12):1928-41.
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal CircuitsJoVE, (no. 133)
Kidins220/ARMS is a novel modulator of astrocyte physiology66th SIF National Congress, Genova, Italy.
Kidins220/ARMS is a novel modulator of astrocyte physiology.XII European Meeting on Glial Cells in Health and Disease, Bilbao, Spain.
The neuronal protein Kidins220/ARMS is a functional mediator of nervous system development, maturation and plasticityXVI Congress of Italian Society for Neuroscience, Cagliari, Italy.
The RhoGEF DOCK10 is essential for dendritic spine morphogenesisMolecular Biology of the Cell, vol. 26, (no. 11), pp. 2112-2127
Klf9 is necessary and sufficient for Purkinje cell survival in organotypic cultureMolecular and Cellular Neurosciences, vol. 54, pp. 9-21
Purkinje Cell Maturation Participates in the Control of Oligodendrocyte Differentiation: Role of Sonic Hedgehog and VitronectinPLoS ONE, vol. 7, (no. 11)
A trio-rhoA-shroom3 pathway is required for apical constriction and epithelial invaginationDevelopment (Cambridge), vol. 138, (no. 23), pp. 5177-5188
Function of Rho GTPase signalling during postnatal Purkinje cell differentiation.10th Conference of French Neuroscience Society, Marseille, France.
RhoQ/TC10 is essential for dendritic spine morphogenesis in cerebellar Purkinje cells.VIIth Conference on small GTPases, Poitiers, France.
Gene expression profiling of RhoGTPase Signalling during postnatal Purkinje cell differentiation.7th FENS Forum Meeting, Amsterdam, Netherlands
Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosisCell Death and Differentiation, vol. 17, (no. 12), pp. 1928-1941
Gene expression profiling of RhoGTPase Signalling during postnatal Purkinje cell differentiationConference Jacques Monod "Regulation and function of small GTPases"