Alessandra Romei

PhD Student Fellow
PhD Student

Contacts

Largo Rosanna Benzi 10, 16132 Genova
+39 010 5558202

About

Professional Experiences:

November 2015 - present:
PhD in the context of the International Training Program ECMED (The extracellular matrix in epileptogenesis) - Italian Institute of Technology ; Center for Synaptic Neuroscience (Genoa, Italy. Supervisor: Prof, Fabio Benfenati.
Theme: Development of MEA-based in vitro and ex vivo models of epileptogenesis and seizures for primary drug screening.

Techniques: Multi-electrode array recordings on primary neuronal cultures, slice electrophysiology on acute brain slices by means of the CMOS-MEA system; patch clamp on primary and iPSC-derived neurons.

October 2014; January – July 2015:
Internship - CIRB Collège de France ; Team “Dynamic and Pathophysiology of Neuronal Networks” (Paris, France)
Theme: Implication of the cortical inhibitory network in the mechanism of action of High Frequency Stimulation of the Subthalamic Nucleus.

Techniques: in vivo single-unit and multi-channel recordings with silicon probes on anesthetized mice, optogenetics, animal perfusion, histochemistry and immunohistochemistry, fluorescence microscopy and some confocal microscopy, data analysis (Klustakwik and MatLab).

May-June 2014:
Internship - Laboratoire Neurosciences Paris-Seine ; Team “Neurophysiology and Behaviors” (Paris, France).
Theme: Characterization of the dopaminergic response to ethanol in the Ventral Tegmental Area, in case of pre-exposure to nicotine.

Techniques: in vivo extracellular single-unit recordings on anesthetized mice, intra-venous injections of drugs and pharmacological agents, immunohistochemistry.

July – December 2012:
Internship - Laboratorio di Fisiologia, Università di Firenze (Sesto Fiorentino, Italy).
Theme: Chemo-mechanical coupling in muscular contraction, studied on skinned fibres from rabbit psoas muscle.

Education:

  • 2013-2015: Master’s degree in Integrative Biology, specialization in Integrated Cellular Neuroscience - Université Pierre et Marie Curie (Paris, France).

  • 2009-2012: Bachelor’s degree in Biology - Università degli Studi di Firenze (Florence, Italy) Final mark 110 and honors.

  • Feb – Jul 2012: Erasmus - Université Pierre et Marie Curie (Paris, France)

Selected Publications

https://academic.oup.com/brain/article/141/4/1000/4931564

https://academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhy079/4975489?redirectedFrom=fulltext